The purpose of this study was to determine and test the effectiveness level of smart seminar application in the learning of Islamic Religion with a case study at Raharja University, Tangerang City, with an experimental approach. The data collection technique uses a test. This study took 74 samples, consisting of 37 control groups, i.e. groups that were not given treatment, or groups that did not use the Smart Seminar application, and 37 students as experimental classes, or groups who were treated were groups who used the Smart seminar application. To test whether the application of smart seminars in the teaching of Islamic subjects is effective, the one-way Analysis of Variance (ANOVA) test is used, but first the distribution data groups must have normality distribution and come from homogeneous data groups. From the normality test table and the homogeneity test table, the Asymp value is obtained. Sig. (2-tailed) 0.318> 0.05 and sig 0.958> 0.05 this shows that the data is normally distributed, and coming from a homogeneous data group it meets the requirements to be continued in the Analysis of Variance (ANOVA) test to test whether there is the effectiveness of the use of the Smart Seminar application in learning Islam at Raharja University. From the ANOVA test results obtained that the calculated F value of 196.236 and a sig value of 0.000 <0.05, this shows that the use of the Smart Seminar Application is very effective in learning Islam at Raharja University. Keywords: Application, Smart Seminar, Learning.