Mild cognitive impairment (MCI) is known as an early stage of cognitive decline. Amnestic MCI (aMCI) is considered as the preliminary stage of dementia which may progress to Alzheimer’s disease (AD). While some aMCI patients may stay in this condition for years, others might develop dementia associated with AD. Early detection of MCI allows for potential treatments to prevent or decelerate the process of developing dementia. Standard methods of diagnosing MCI and AD employ structural (imaging), behavioral (cognitive tests), and genetic or molecular (blood or CSF tests) techniques. Our study proposes network-level neural synchronization parameters as topographical markers for diagnosing aMCI and AD. We conducted a pilot study based on EEG data recorded during an olfactory task from a group of elderly participants consisting of healthy individuals and patients of aMCI and AD to assess the value of different indicators of network-level phase and amplitude synchronization in differentiating the three groups. Significant differences were observed in the percent phase locking value, theta-gamma phase-amplitude coupling, and amplitude coherence between the groups, and classifiers were developed to differentiate the three groups based on these parameters. The observed differences in these indicators of network-level functionality of the brain can help explain the underlying processes involved in aMCI and AD.

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Non-invasive gamma entrainment has shown promising results in alleviating cognitive symptoms of Alzheimer's disease in mice and humans. In this study, we examine improvements in the synchronization characteristics of the brain's oscillations induced by 40Hz auditory stimulation based on electroencephalography data recorded from a group of dementia patients. We observed that when the quality of entrainment surpasses a certain level, several indicators of brain synchronization significantly improve. Specifically, the entrained oscillatory activity maintains temporal phase stability in the frontal, parietal, and occipital regions, and persistent spatial phase coupling between them. In addition, notable theta-gamma phase-amplitude coupling is observed in these areas. Interestingly, a high theta power at rest predicts the quality of entrainment. We identify differentiating attributes of temporal/spatial synchronization and cross-frequency coupling in the data of two groups with entrained and non-entrained responses which point to enhanced network synchronization caused by entrainment and can explain its potential therapeutic effects.