Purpose: Cavity disinfection, in addition to routine caries removal methods, is recommended to eliminate the microorganisms. The aim of this study was to compare the effect of various systems Er,Cr:YSGG lasers, diode lasers and FotoSan and agents Corsodyl; Cervitec and Cervitec Plus and Fluor Protector-on the nanoleakage of compomer restorations when used for cavity disinfection. Materials and methods:A total of 40 intact human deciduous molar teeth containing Black V cavities (3×2×1.5 mm) on the buccal and lingual surfaces parallel to the cementoenamel junction were randomly divided into 8 groups according to the cavity disinfection methods. The antibacterial agents and systems were applied according to the manufacturer's instructions. Restorations were completed using a compomer. The restored teeth were then subjected to thermocycling for 500 cycles in a water bath at 5°C and 55°C with a dwell time of 30 seconds. After the thermocycling procedures, 1-mm sticks were obtained from the center of each cavity to prepare for the nanoleakage test. After the teeth were sectioned, they were immersed in 50 wt % ammoniacal silver nitrate solution for 24 hours and dipped in photo-developing solutions for 8 hours with fluorescent light irradiation. The samples were examined under a scanning electron microscope (SEM). The non-parametric Kruskal-Wallis and Mann-Whitney U test (p˂0.05) were applied.3 This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Results:The Er,Cr:YSGG laser group showed significantly less nanoleakage than all of the tested groups (p<0.01). The diode laser, Fluor protector and FotoSan groups showed similar nanoleakage to that of the control group (p>0.05). The Corsodyl (p<0.01) and Cervitec (p<0.001) groups showed significantly higher nanoleakage than the control group.Conclusions: Er,Cr:YSGG laser irradiation which showed lower nanoleakage scores from either control or tested groups can be recommended for cavity disinfection can be recommended for cavity disinfection. Additionally, a diode laser and FotoSan, which have antibacterial effects and no negative effect on leakage, can be used for cavity disinfection. ÖzKavite dezenfeksiyonunun kompomer restorasyonların nanosızıntısına etkileri: taramalı elektron mikroskobu ve enerji dağılımlı x-ray analizi Amaç: Rutin çürük uzaklaştırma yöntemlerine ek olarak kavite dezenfeksiyonu mikroorganizmaların eliminasyonu için önerilmektedir. Bu çalışmanın amacı farklı sistemlerin; Er,Cr:YSGG lazer, diod lazer, FotoSan ve ajanların; Corsodyl, Cervitec, Cervitec Plus, Fluor Protector kavite dezenfeksiyonu amacıyla kullanımında kompomer restorasyonların nanosızıntısına etkilerinin incelenmesidir. Gereç ve yöntem: Bukkal ve lingual yüzlerinde mine sement sınırına paralel sınıf V kaviteler (3×2×1.5 mm) bulunan 40 adet insan süt azı dişi kavite dezenfeksiyon yöntemine göre 8 gruba ...