Two groups of patients suffering surgical infections were treated with fosfomycin. The first includes 21 suppurating dermic or soft underlying tissue lesions. The second group includes 29 surgical abdominal infections. The bacteriology of the first group was made up of gram-positive and gram-negative germs predominantly S. aureus and E. coli, all the isolated species appeared to be sensitive to fosfomycin. In the second group a gram-negative bacterial flora predominantly E. coli was obtained; with a sensitivity to this antibiotic of 90.5%. Surgical treatment accompanied the treatment with fosfomycin. In the first group, all the patients were cured with the oral administration of 2–6 g/day and in an average time less than that of the similar control group which did not receive the antibiotic. In the second group surgical treatment was necessary in 25 of the 29 patients and in all of them parenteral treatment was done with fosfomycin, preferably intramuscularly and in general the dosage was 4 g daily. All patients were cured except for one who was not operated on and who suffered from a fever of undetermined origin.

Location-based services (LBSs) have become a profitable market because they offer real-time and local information to their users. Although several benefits are obtained from the usage of LBSs, they have opened up many privacy and safety challenges because a user needs to release his/her location. To tackle these challenges, many location-cloaking techniques have been proposed. Even though these solutions are effective in protecting either location privacy or location safety, they do not provide unified protection. Furthermore, most of them do not address the potential bottleneck in the anonymity server as a high demand of location and safety protection is requested. Finally, they do not take into account the potential impact of processing a large amount of location-cloaked queries. This paper deals with the efficient construction of location-cloaking areas for many users, who have both privacy and safety requirements. To achieve this goal, the construction of location-cloaking areas is carried out in batches. The LBSs’ batch processing takes advantage of users who are close to each other and who have similar requirements. Two batching techniques to build cloaking regions are analyzed using simulations. Empirical results show our techniques are able to balance the anonymizer workload, quality of location privacy and safety protection, and LBS workload.

We herein describe a family with thyroid hormone resistance. Thyroid hormones and basal TSH were elevated. Pituitary tumor or abnormality in thyroid hormone binding proteins were ruled out by appropriate tests. Mother and sister of the propositus presented similar abnormal hormonal features but no hyperthyroidism. Initially the patient was treated with carbimazole (30 mg/day): three months later a dramatic increase in the size of the thyroid gland and in TSH levels (12.5 to 28 mU/l) were noted. Thereafter, dextrothyroxine (D-T4) and 3, 5, 3'-triiodothyroacetic acid (TRIAC) were given consecutively and treatment was accompanied by a decrease of TSH levels (2 mU/l) but thyroid hormone remained elevated. The symptoms and signs of hyperthyroidism improved with the addition of propranolol (30-60 mg/day). In conclusion, the present report describes a new family with the syndrome of THR and variable degrees of involvement among relatives. We suggest the usefulness of TRIAC therapy to decrease TSH levels and propranolol to improve thyrotoxicosis due to pituitary resistance to thyroid hormone.

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