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A high performance liquid chromatographic (HPLC) method suitable for routine determination of lamotrigine in a dissolution medium and tablet formulation has been developed. Chromatographic separation was performed on a Gemini C18 (250 mm  4.6 mm i.d., 5 mm) column using a mobile phase of 0.05 M (NH 4 )H 2 PO 4 -acetonitrile (68:32, v/v, pH 2.68), delivered at a flow rate of 1.2 mL/min and detected by ultraviolet at 265 nm. The method was validated for specificity, linearity, accuracy, and precision. Additionally, the conditions of the dissolution test for lamotrigine tablets were presented by using: paddle at 50 rpm stirring speed; medium volume of 900 mL; temperature at 37 + 0.58C; and pH 1.2 HCl solution, pH 4.5 acetate buffer and pH 6.8 phosphate buffer as dissolution media. The proposed analytical and dissolution methods were applied successfully for the quality control of commercial lamotrigine tablets and the comparison of in vitro performances of their products.

Background: Risperidone is an atypical antipsychotic drug with potent serotonin and moderate dopamine antagonistic properties. It possesses good bioavailability following oral administration. Risperidone is primarily converted by the cytochrome P450 2D6 (CYP2D6) and 3A4 (CYP3A4) enzymes to 9-hydroxyrisperidone, its active metabolite with equivalent potency to the parent compound. Objective: This study aimed to compare the pharmacokinetics and determine bioequivalence of two risperidone immediate release oral tablets, a test formulation (Risperidone GPO ® or "Test") and a reference formulation (Risperdal ® or "Reference"). Method: A single-dose, randomized, fasting, 2-period, 2-sequence, crossover study design with a 2-week washout period was conducted in 23 healthy Thai male volunteers. Blood samples were collected predose and at 0.

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