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Incorporation of the seismic response control system plays a vital role in structural engineering. Conventional method of structural design involves the higher flexibility and lower damping characteristics during the application of seismic loads which leads to inelastic deformation to an acceptable limit. Modern technique of seismic energy dissipation aims towards achieving stringent performance requirement. This paper aims towards analysis of structural response of the benchmark building with semi active damper namely magnetorheological damper. The magnetorheological damper work depends on the Structural Control Algorithm and Current input. G+5 Reinforced Concrete Building response is studied with a connection of large scale 200KN MR Damper (MRD) for three proposed numerical models, namely Kelvin Voight Model, Hyperbolic Tangent model and Maxwell Non-linear Slider model. The predictive ability of numerical models is analyzed for varying current. For simulating seismic application three earthquake data were considered, El Centro, Imperial Valley and Northridge. Numerical models of MR Damper are studied under varying current and exponential value. The comparison of displacement and base Shear of the structure response gives satisfactory response in the analysis.

Objective To develop Favipiravir, based predictive models of coronavirus disease 2019 (COVID-19) from small molecule databases such as PubChem, Drug Bank, Zinc Database, and literature. Methods High Throughput Virtual Screening (HTVS) using different computational screening methods is used to identify the target and lead molecules.  CoMFA (Comparative Molecular Field Analysis) is a 3D-QSAR procedure depending on information from known dynamic atoms and eventually permits one to plan and anticipate exercises of particles.  These two analysis is used to train predictive models. Results The predictive model achieved the highest accuracy score with a relatively small dataset size can be a subject of overfitting. Datasets with over 500 samples demonstrate an accuracy of about 85–95%, that can be considered as very good. Conclusions From the result it is observed that Increasing level of potassium, sodium and nitrogen will lead to burst lipid bilayer membrane of virus which cause RNA replication rapidly. However, low level of sodium, potassium and nitrogen will help in the DNA polymerase inhibition and replication can be stopped. The best developed QSAR model in terms of the druggability and activity relation has been selected over the parent Favipiravir molecule for designing COVID-19 drugs may lead towards pharmaceutical development in future.

This paper presents a novel buckling-restrained brace (BRB) where the inner core is restrained by a concrete infilled Expanded Polystyrene Sheet (EPS) instead of the conventional concrete infilled tube section, to resist inner core buckling. It serves two purposes, firstly, the EPS is a ductile material, which is favourable in terms of seismic performance and, secondly, the outer construction material has better corrosion resistance. Thus, the life of the steel core can be prolonged. In this study, 6 BRB specimens were prepared, of which 3 BRB specimens were infilled with concrete and the remaining 3 BRB specimens with concrete and EPSs, in order to study their performance under cyclic loading. Three different core heights, all with the same core thickness, were adopted. The test results indicate that the load-carrying capacity of this novel BRB is higher than the conventional BRB. Further, the length of the steel tube also affects the strength of the seismic disaster mitigation system. Lastly, a numerical study on a single bay RC frame, with and without BRB subjected to time history analysis, was conducted to check the global performance of this novel system. It was found that the structural responses had substantially decreased.

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