Mucormycosis is also known as “Black Fungus”. It has come into light as mucormycosis as a formidable infection in patients with severe and fatal immunosuppression. Heavy intake of steroids with no vitamin supliments and immune supplementation has led to further deterioration of health of covid-19 recovered patients. Patients are reporting back to the hospital with complains of the black fungus, UTI, recurrent diarrhoea and compromised lungs functioning. According to the doctors, cases of mucormycosis are being seen among Covid patients who were administered steroids to treat the symptoms, particularly among who are suffering from diabetes, cancer and other co-morbidities. The most prominent predisposing factors are immunosuppression followed by neutropenia and haematopoietin, stem cell transplantation, uncontrolled DM, burns, morbidity leads to increased demand of antifungal drugs. Black fungus is manifest in the air pockets located behind the forehead, nose, cheekbones and in between the eyes and teeth. Black fungus is spread to the eyes, lungs and spread even to the brain. Treatment of this fungal infection requires a multi-disciplinary approach consisting of eyes surgeons, ENT specialist, general surgeons, neurosurgeons and dental maxillofacial surgeons, among other, and the institution of the Amphotericin-B as an antifungal medicine. From COVID-19 pandemic, many reports came of the very high incidence of COVID-19 induced mucormycosis in patients with diabetes and who are on steroids during their stay in hospitals.

Current pandemic of coronavirus disease 2019 (COVID-19) by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in huge global mortality with daily increment of cases. Though at present different vaccines are available but complete vaccination at the country level needs subsequent time interval. In present condition of stress and fear, bioactive compounds from different medicinal plants are screened using computational approaches to be used as a potential drug candidate. These in silico approaches have found few phyto-compounds that can be used against therapeutic protein targets of SARS-CoV-2. These natural compounds might have fewer side effects compared to chemotherapeutic agents that are re purposed in this pandemic situation. Though convincing results are obtained from in silico approaches but it warrants further studies to be marketed as a recommended drug. Foreseeing the current pandemic and positive computational results on natural products, these can be considered for enhancing immunity and prevention. Decoction of therapeutically beneficial medicinal plants like neem (Azadirachta indica) and giloy (Tinospora cordiofolia) can be recommended due to easy availability, cost effective nature and easy implementation at community level. These natural products possess anti- inflammatory, antipyretic, fungicidal and antiseptic properties which can prevent from COVID infection and post-COVID complications, including attack from opportunistic pathogens.