Systemic lupus erythematosus (SLE) is a chronic inflammatory disease that may affect the joints, skin, kidneys, lungs, nervous system, and serous membranes and/or other organs. Lymphadenopathy is characterized by changes in the characteristics and size of the lymph nodes. It results from reticuloendothelial proliferation secondary to inflammation, infection, or malignancies. Lymphadenopathy is common in SLE. It has been reported that lymph node enlargement is observed in 25-67% of SLE patients. We reported this thirty-three-year patient with presented with lymph node enlargement in cervical, axillary, and inguinal, joint pain, renal involvement and respiratory involvement diagnosed as Systemic lupus erythematosus according to ACR/EULAR criteria immunological and clinical domain SLICC (systemic lupus international collaborating clinics. In conclusion, lymphadenopathy is a manifestation in SLE. As illustrated by the case presented here, it can precede the diagnosis of SLE by many years; It is possible that the factors that induce lymph node proliferation are also responsible for the development of autoantibodies.