The objective is to verify the effects of pesticides on the health of farmers in the southern region of Brazil, as well as the possible symptoms and cases of intoxication. This study has a quantitative, descriptive and exploratory approach, carried out in 12 agricultural locations in the municipality of Serra Catarinense. This research was approved by the research ethics committee and was applied through a structured questionnaire to 79 farmers who grow grains in the conventional cultivation system. The pesticide most used by farmers was glyphosate, followed by acephate. Of the individuals, 21.5% reported that they had suffered poisoning by pesticides by the respiratory route (58.8%). In addition, 28% had three symptoms of intoxication, demonstrating possible probable cases of intoxication. And 41% of workers reported headaches as a predominant symptom in applications with the use of pesticides, followed by dizziness/vertigo (16%).Farmers who use PPE during the preparation of the pesticide spray are neither chronic diseases (p<0.003) nor psychological problems (p<0.000). All four individuals who had cancer, all also eat while applying pesticides (p<0.049). The exposure to pesticides causes changes in the organism of those exposed, using them more vulnerable to health problems.