Objectives: The present examine was going to evaluate the pain killer, anti-inflammatory, and CNS depressant activities of the methanolic extract of the Sonneratia clear leaves (MESAL). Materials and methods:By using carrageenan-induced inflamed method anti-inflammatory effects regarding MESAL were studied right here at the dose of 150 mg/kg and 300 mg/kg body mass. Analgesic activity of MESAL was evaluated by applying formalin-induced licking and gnawing at activities in mice at a dose of 200 mg/kg and 400 mg/kg body weight. The CNS depressant activity has been measured by observing typically the reduction of locomotors in addition to exploratory activities on view discipline and hole cross assessments at a dose regarding 200 and 400 mg/kg bodyweight.Results: Statistical analysis revealed that dose of 400 mg/kg displayed pct of protection (86.29%) of licking in addition to biting of formalin-induced rodents at late phase compared to diclofenac sodium (78.23%). The dose of one hundred fifty mg/kg showed sustained inhibited (17.27% and twenty-two 94%) of paw edema at the 2 nd and 3 rd hour compared with standard diclofenac sodium (15.93% and 17.47%). Additionally, doses of 3 hundred mg/kg caused the higher percent of sustained inhibition regarding paw edema at every single hour compared with common diclofenac sodium. Besides, the flower extract also had considerable (p<0.05) dose-dependent CNS depressant activity.Bottom line: Current study recommends that this methanolic extract of Sonneratia alba leaves has important analgesic, anti-inflammatory and CNS depressant properties.