Increased contamination of pharmaceutical compounds and their presence have led to real health problems. In this study used Poly (Graphene oxide/polyvinylpyrrolidone/acrylic acid (GO/PVP/AAc) as the innovator composite/hydrogel, were tried out atenolol drug. It has been proven to be effective in laboratory elimination of solutions. The composite prepration via free radical polymerization by using Specific ratios between (PVP/AAc) hydrogel and graphene Oxide (GO). The innovator adsorbent was estimated characterized by FT.IR, and FE-SEM. A suite adsorption tests were studied using to performed the Optimal conditions Of which contact time, pH. Dosage of adsorbent, ionic strength, and temperature. The kinetic experimental data were carried out via two model first pseudo order and second pseudo order, the adsorption proocess followed Pseudo second -order kinetic model with correlation coefficients greater than 0.999. The adsorption isotherms of composite could be illustrated well by the Freundlich Langmuir and Timken equations, The process of Atenolol adsorption on composite was depended on Freundlich and Timken isotherms more than other. The study discusses the thermodynamic parameters including changes in enthalpy, entropy, and Gibbs free energy.

Objective: The objective of this study was to estimate the performance of Acrylamide-malice acid (AAM_MA) hydrogel preparatory by free radical polymerization to loading/release Atenolol and Ciprofloxacin drugs from aqueous solution to be used in a controlled release system.Methods: Free radical polymerization method has been used to prepare (AAM-MA) hydrogel. The prepared hydrogel was characterized by Fourier transform infrared (FTIR), Thermal Gravimetric Analysis/Derivative Thermal Gravimetric (TGA/DTG) and Field Emission Scanning Electron Microscopy (FE-SEM) techniques. The pH-dependent swelling behavior was investigated in addition to the effective ionic strength on adsorption and release system of the drug in vitro.Results: Results showed that the highest swelling ration in pH=7.4 and the same value of pH for the release of the drug. Thermal analysis test for prepared hydrogel showed good thermal stability. The hydrogel showed a negative effect with an increase saline contact Calcium carbonate appeared to have highly effect on releasing drugs from the polymeric network.Conclusion: Higher ability of poly (AAM-MA) hydrogel to act as a carrier for the Ciprofloxacin and Atenolol with highest swelling and releasing under following conditions: at pH 7.4, at temperature 37 °C and the effect of ionic strength (charge/ratio) which indicate that the smaller radius have less effect on release and the largest charge have negative effect on release ratio that attributed to cation formation inter and intra complex surface hydrogel.

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