The aim of this study was to determine the effectiveness of Astragalus hamosus root phenolic extracts (APE) on blood profiles in albumin mice. Twenty male mice were divided into 4 groups, each with five mice, that were treated orally with a plant extract in three doses (0.3,0.5 and 1.3 mg.ml-1). The chemical compositions of (APE) were analyzed using Gas chromatography-mass spectrometry (GC–MS). In contrast to the results, Thymol a was the main active volatile monoterpenoid phenol ingredient in the phenolic compounds. Also, the results showed that the dose of 1.3 mg.ml-1 of (APE) was the powerful extract that reduced levels of cholesterol (CHO), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL), and triglycerides (TG), respectively, compared with the control treatment. Besides, the effective extract increased high-density lipoprotein (HDL) level with high significant differences compared with the control in serum mice blood. Also, the dose 1.3 mg.ml-1 increased the Monocyte count, granulocyte count, Hemoglobin with no changing in RBC, WBC level compared to the control treatment. In addition, of (APE) reduce Platelet count and Lymphocyte in the blood of the mice after four weeks.