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<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">Surgical site infection (SSI) occurs in a considerable portion of patients after closure of surgical incision. The newer synthetic absorbable sutures consistently display proven advantages for wound healing over naturally derived suture. The study is planned to evaluate the safety and efficacy of MITSU™ Polyglactin 910 Suture with Coated Vicryl^® Polyglactin 910 Suture in a closure of surgical incision. </span></p><p class="abstract"><strong>Methods:</strong> <span lang="EN-IN">This is a prospective, multicentric, post-marketing, randomized, controlled, single-blinded, comparative study in a closure of surgical incision where general soft tissue approximation and/or ligation is required during an elective surgery. Patients are randomized to 1:1 ratio in the test (MITSU Polyglactin 910 Suture) and reference (Coated Vicryl Polyglactin 910 Suture) groups. Patients are monitored for safety and efficacy outcomes, viz. the rate of SSI, hospital length of stay, overall wound dehiscence and any adverse events/serious adverse events at post-procedural, 14 days, 30 days and 6 months of surgery. The rate of SSI for each group will be analyzed using one sided T-test. The effect of type of suture on SSI and overall wound dehiscence will be evaluated with chi-square test. Length of stay in hospital will be evaluated with student’s t-test.</span></p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">The study has been designed to compare the safety and efficacy of MITSU Polyglactin 910 Suture versus Coated Vicryl Polyglactin 910 Suture in a closure of surgical incision.  </span></p><p class="keywords"><strong><span lang="EN-IN">Trial registration</span></strong><span lang="EN-IN">: The trial protocol has been registered with the clinical trial registry of India (CTRI/2017/01/007717; registered on 17/01/2017).</span></p>

Breast calcifications are too small to feel. They can be seen on mammography. They are common and found in about half of all mammograms of females aged 50 and older and one in 10 mammograms of young women. The initial assessment of calcification is made to determine if they confirm well established benign morphologies. Calcifications with benign morphologies require no further investigation. If the characteristics of the calcification are such that they cannot be reliably classified as due to benign processes, then additional evaluation is indicated. MATERIAL AND METHODS: A total of 100 mammograms showing calcification in females of different age group were studied. 4 age groups were included 35-44, 45-54, 55-64 and 65-74yrs.The size, morphology and distribution of calcification was studied. OBSERVATION AND CONCLUSION: Calcification is a frequent finding in both benign and malignant breast diseases. Distribution of calcification is often a clue to their etiology when no evident mass is present.

Preterm premature rupture of the membranes (PROM) is associated with significant maternal morbidity and perinatal mortality. With an increasing era of infertility, the main interest of an assisted reproductive technology specialist is to increase the take-home baby rate. Here authors present report on the outcomes of prolonged preterm PROM cases facilitated with expectant management. Report is based on the medical records of six women with preterm PROM between 16-31 weeks of gestation who gave their consent to continue the pregnancy. These women were diagnosed with PROM by the litmus test and per speculum examination. Ultrasound scan and clinical investigation, which included complete blood count and C-reactive protein level, were performed in all cases. Prophylactic antibiotics were administered to prevent the infection and increase the latency period. All six babies (100%) were delivered successfully. There was no foetal mortality and maternal morbidity observed. Expectant management in preterm PROM cases can increase the survival rate and hence the take-home baby rate.