Zoonotic diseases are the major public health problems worldwide. Nearly two third of the zoonotic diseases and majority of emerging infectious diseases exerting heavy public health and economic burden to the global community originate from animals. Pre experimental one group pre-test post-test research design was adopted to detect the level of effectiveness of structured teaching on prevention of zoonotic diseases among high school children. The data was collected from 100 samples using convenient sampling technique The data was obtained using Structured knowledge questionnaire. The study finding showed that pre-test score 82(82%) of the high school children had below average knowledge and 18(18%) had average knowledge regarding prevention of selected zoonotic disease. After the structured teaching based on the knowledge out of 100 samples, 34% had average knowledge, the 66% had good knowledge .The post-test mean (28.84) was apparently higher than that of mean pre-test (11.13) knowledge score. The calculated t value (4.97) was greater than the table value (t=1.98) at 0.05 level of significance.. Hence our research hypothesis is accepted. The structured teaching programme was effective in I ncreasing knowledge of high school children regarding prevention of zoonotic diseases.chi square test to associate the level of knowledge and selected demographic variable.