OBJECTIVE: To estimate the value of Alkaline Phosphatase in cancer breast patients in a tertiary care hospital. MATERIAL AND METHODS: The study was conducted to estimate the value of Serum Alkaline Phosphatase in 50 cancer breast patients and 50 normal patients of same age as a control group. RESULTS: The level of serum Alkaline Phosphatase was signicantly increased (p<0.05)in cancer patients compared to the control group. CONCLUSION: There is an increase in serum Alkaline Phosphatase in cancer patients compared to the control group and can be a prognostic markers for the progress of the disease.

Objective- To evaluate and compare the level of TSH in premenopausal women (reproductive age group) and post-menopausal women. Material And Methods- The study was carried out on 100 premenopausal and 100 post-menopausal women attending Out Patient Departments at RIMS, Ranchi, during the period of January 2018- October 2019. Study Design: - Observational Study. Statistics- Statistical analysis was done using SPSS software. The data were represented by counts, percentage and mean ± standard deviation. Statistical analysis of TSH was done by t-test to compare these parameters in premenopausal and post-menopausal women. A p-value of <0.05 was considered statistically signicant. Result- In the present study, we found that the mean serum TSH level in postmenopausal women 2.72 (± 1.06) uIU/ml was comparatively higher than premenopausal women 2.29 (±1.12) uIU/ml and the difference between the two was statistically signicant (p<0.001). Conclusion- Thyroid hormones play an important role in maintaining normal reproductive behaviour by directly effecting on gonadal function and indirectly interacting with sex hormone binding protein. Alteration of thyroid hormone level leads to menstrual irregularities and infertility. The present study clearly demonstrated that there was signicant increase in TSH levels in post-menopausal women and was statistically signicant. Thus, it proved that postmenopausal women are more prone to subclinical hypothyroidism.