Machine learning with classification can effectively be applied for many applications, especially those with complex measurements. Therefore classification technique can be used for prediction of diseases like cancer, liver disorders and heart disease etc which involve complex measurements. This is part of growing demand and much interesting towards predictive diagnosis. It has also been established that classification and learning methods can be used effectively to improve the accuracy of prediction of a diseases and its recurrence. General TermsMachine learning, support vector machine, random forest, kernels, linear, non linear, radial basis function and sigmoid.