Background and Purpose/Objective: Evidence supporting the effect of community-based cancer-specific physical and occupational therapy (PT/OT) services on cancer-related disability is limited. We examined the effect of community-based outpatient cancer-specific PT/OT for performance-based and patient-reported outcomes (PROs) for adults with cancer. Methods: This retrospective, pre/posttreatment study included 185 adults seen for cancer rehabilitation (PT/OT). Demographic and clinical data were patient-reported. Patient-Reported Outcomes Measurement Information System (PROMIS) measures included global physical health (GPH) and global mental health (GMH) scale (10 item); physical function (PF; 4-item), and ability to participate in social roles and activities (SRA; 4-item). Performance-based measures included hand grip strength (HGS) Rehabilitation Oncology

e19325 Background: Adults with cancer often struggle with persistent symptoms that negatively impact quality of life (QoL), physical and social function. Cancer rehabilitation delivered by a trained physical and/or occupational therapist (PT/OT) is recommended. However, evidence is lacking regarding the impact of community-based PT/OT on patients' functioning. Methods: We assessed adults (≥ 18 years) who completed cancer-specific visits in routine care at two outpatient rehabilitation clinics. Demographic and clinical data was patient-reported. Patient-Reported Outcomes Measurement Information System (PROMIS) measures included: Global Physical Health (GPH) and Mental Health (GMH) scale (10 item); Physical Function (PF; 4-item), and Ability to Participate in Social Roles and Activities (SRA; 4-item). Hand grip strength (HGS) and the Timed Up and Go (TUG) were administered by PT/OT. We compared outcomes collected during the first and final therapy evaluations using paired samples t-test and calculated effect size using Cohen’s d. We used independent t-test to compare mean pre-post change between patients on active treatment versus post-treatment. Results: Patients (N= 185) were predominantly female (75%), 41-64 years old (57%), and majority receiving cancer treatment (58%). Most (N =115, 62%) completed at least one follow-up evaluation over 6 weeks. From pre to post therapy, a significant (p<.05; d = 0 .35-.21) effect was observed for GPH, SRA, HGS, and TUG. There was no difference in the average improvement between active and post-treatment groups. Conclusions: Community-based cancer-specific PT/OT has a significant impact on the well-being and functioning of adults with cancer. Evidence supports the utilization of community-based, cancer-specific PT/OT throughout the cancer-care continuum. [Table: see text]