AIMS:To conduct a meta-analysis of statin-associated type 2 diabetes mellitus (T2D) risk among randomized controlled trials (RCTs) and observational studies (OBSs), excluding studies conducted among secondary prevention populations. METHODS:Studies were identified by searching PubMed (1994-present) and EMBASE (1994present). Articles had to meet the following criteria: 1) follow-up >one year; 2) >50% of participants free of clinically diagnosed ASCVD; 3) adult participants ≥30 years old; 4) reported

Vomiting-induced pneumomediastinum can be a result of barotrauma causing alveolar rupture or Boerhaave’s syndrome. Although a rare cause of secondary pneumomediastinum, Boerhaave’s syndrome allows extravasation of air and fluid due to oesophageal perforation. We report a case of a 20-year-old female who presented with prolonged vomiting during a panic attack. Extensive surgical emphysema and pneumomediastinum were visualised radiologically. A source of oesophageal rupture was not visualised on cross-sectional computed tomography imaging following contrast ingestion. A complication of mediastinitis provided the evidence that this was a case of Boerhaave’s syndrome whereby microscopic perforation of the oesophagus led to secondary pneumomediastinum, rather than vomiting-induced spontaneous pneumomediastinum caused by barotrauma. Recurrent Boerhaave’s syndrome in this case is owed to the patient having previously experienced identical symptoms which spontaneously resolved.