The present study was carried out to investigate the persistence of some pesticides (diazinon and deltamethrin) in water, feeds and milk. The obtained results illustrated that diazinonwas persisted for longer time in water, feed and milk samples than deltamethrin, it disappears within 21 st and14 th day after application in water and feed, respectively, while it disappears within 30 th day after application in milk. Moreover, deltamethrin disappear within 7 th day after application in feed and water, while in milk it disappears within 21 st day after application. We concluded that diazinon and deltamethrin were persisted in milk for longer time than both feed and water. Pesticides contamination of milk and milk products may lead to acute or chronic toxicity for human being representing public health hazards through their cumulative effects.