Children who were at risk for obesity have increased aortic and PAS, subclinical LV and RV dysfunction. These abnormalities were associated with increased hs-CRP. The data suggest that appropriate strategies for weight control are essential not only for obese children but also for those at risk for overweight.

Abnormal HRR1 and delayed SBP response detected during recovery imply a significant correlation with impaired endothelial function and diastolic dysfunction in prediabetics.

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Both systolic synchronicity and diastolic synchronicity were affected in pregnant women compared to nonpregnant women. LV dyssynchrony was significantly correlated with age, multiparity, and BNP level. Early detectable changes in systolic and diastolic synchrony may be present in pregnant women at higher risk of peripartum cardiomyopathy.

Objective: The aim of the study was to investigate the impact of P-maximum and P-wave dispersion on the long term clinical outcome after successful percutaneous balloon mitral valvuloplasty (PBMV) in patients with mitral stenosis (MS) and sinus rhythm. Also to test the correlation between P-variables and right ventricular function and pulmonary artery pressure before and after PMBV. Methods: Eighty-five patients undergoing PMBV were enrolled in this study. We evaluated P-maximum, P-minimum and P-wave dispersion before and one month after PBMV. We studied the changes in pulmonary arterial pressure (PAP), left atrial (LA) dimension, mitral diastolic gradient, and mitral valve area, in addition to the changes in right ventricular function utilizing tissue Doppler assessment both before and after PMBV, in addition the role of the P-wave dispersion in predicttion of late cardiac events. Results: There were significant decreases in mean diastolic gradient, PAP, and LA size and significant improvement in right ventricular tissue Doppler indices after PMBV. Ac- company these hemodynamic changes after PMBV. P-maximum and P-wave dispersion were found to be decreased (P < 0.001). Patients developed cardiac events during follow-up had a higher P-maximum and P-dispersion than those without late cardiac events (P < 0.001). Moreover the changes in P-maxi- mum and P-dispersion before and after PMBV in patients with cardiac events were not significant, while P-maximum and P-dispersion significantly (P < 0.002) decreased in patients without events It was revealed with linear regression and correlation analy- sis that the degree of and the changes in P-maximum and P-wave dispersion were correlated with devel- opment of late cardiac events after PMBV, with Cut-off values of ≥62.8 msec for P-wave dispersion and

118 mes for P-maximum.ROC curve showed AUC of 0.919 for P-wave dispersion and 0.913 for P-maximum (P < 0.001). Conclusion: P-wave maximum and dispersion are significantly increased in patients with mitral stenosis. These changes decreased significantly after PMBV. The P-maximum and P-wave dispersion changes were correlated with significant impairment of right dysfunction and the degree of pulmonary artery pressure. P-maximum and P-wave dispersion could be considered as independent predictors of late outcome of patients with MS after successful PMBV (AF, recurrent hospital admission, embolic phenomenon deterioration of right ventricular function).