Background Substance abuse is a major health problem, associated with multiple clinical correlates. Cognitive dysfunctions were among the most relevant health problems associated with substance abuse among adolescents. The aim of the study is investigate the main cognitive domains affected in a sample of adolescents with substance use disorders. A case-control comparison was performed between 100 substance abusers versus 40 controls. The Mini-International Neuropsychiatric Interview v.5, Addiction Severity Index, Wisconsin Card Sorting Test, socioeconomic scale, and multiple historical variables investigated. Results Substance abusers showed higher mean than control as regard all other WCST domains. The difference between two groups was statistically significant. Cannabis substance mostly affects early conceptualization and problem-solving abilities, while inhalants affect predominantly sustained attention, and alcohol mostly affect cognitive flexibility. Polysubstance use is more harmful to most of the executive function domain than mono substance use. Conclusions The substance use disorders are a major health problem accompanied cognitive dysfunction among adolescents and associated with increased rates of executive dysfunction. Cognitive flexibility, sustained attention, problem-solving abilities, and early conceptualization are the most domains affected.

Background: Substance abuse is a significant public health concern with numerous clinical implications. Cognitive dysfunctions were amongst the most significant health issues connected with teenage substance usage. Aim: This study aimed to detect the factors affecting the cognitive domains dysfunction among adolescent with substance use disorder. Patients and methods: Among one hundred substance abusers and forty controls, a case-control comparison was undertaken. Several historical variables and the Addiction Severity Index, the Wisconsin card sorting test, and the socioeconomic scale are explored. Results: Parent's education affecting all executive functions domains in a protective way. Grow up in an urban area has a significant positive effect on executive functions generally and specifically in our patients. Schooling has a protective effect against executive function deterioration in adolescents with substance use. The severity of substance use is proportionate to the severity of executive function deterioration. The socioeconomic status has a protective effect on the executive dysfunction of adolescent with substance use disorder. Conclusion: Smoking, cannabis and alcohol, are the most widely used substances by adolescents. Multiple executive function domain affection and poly substances are the common role not the reverse in adolescents.

Background Insomnia is the most common sleep disorder affecting sleep quality and quality of life among women during the perinatal period. The aim of the study is to study the frequency of insomnia and sleep quality among perinatal women and their effect on quality of life: 131 participants; 64 perinatal and 67 control groups from the outpatient clinics of Suez Canal University Hospital, Ismailia, Egypt. DSM-5 criteria were used to diagnose insomnia. Sleep quality was assessed using PSQI, and SF-36 questionnaire was used for assessment of health-related quality of life. Results Insomnia was statistically significant higher among the perinatal group than the control; 28.1% and 10.4%, respectively (P < 0.05). The perinatal women had poor sleep quality as compared with the control group with a higher mean global PSQI score; 8.02 ± 2.97 and 4.97 ± 2.45, respectively (P < 0.05). The quality of life in the perinatal group was lower than the control group with scores of 54.96 ± 14.63 versus 62.34 ± 14.63, respectively. Conclusions Insomnia and poor sleep quality are found in higher frequency in perinatal women than their counterpart control. The study also showed a significant impact of these changes on maternal HRQoL.