Favism is most common in those who have G6PD deficiency from the Mediterranean region. As hemolytic anaemia is the most common complication of G6PD deficiency, and it can be life-threatening in certain people. Infection, hyperglycemia, certain meals, and certain drugs can all cause hemolysis therefore, the most prevalent enzymopathy is glucose-6-phosphate dehydrogenase (G6PD) deficiency, which affects an estimated 400 million individuals, globally. Exposure to some medicines might cause hemolytic anaemia. The most important management technique is to avoid oxidative stresses by avoiding a hemolytic crisis. Also, avoidance of exposure to food and medicines that causes  hemolytic anaemia episodes This review looks at etiology, epidemiology, pathopysiology, evaluation and management of the disease.