Introduction: Atherosclerosis and cardiovascular disease risk is enhanced in various connective tissue diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and antiphospholipid syndrome. A number of alterations in lipid profiles have also been documented which may further enhance risk for CHD in SLE. The main aim of the study was to assess the prevalence of dyslipidemia and to evaluate the role of corticosteroids in patients with connective tissue disorders. Material and methods: The study is a prospective clinical study in which 30 patients were included into the study. Patients who were newly diagnosed with Connective tissue disorders were taken. A detailed history, clinical examination and investigations such as CRP-ESR, RA and ANA were performed depending on the requirement. Results: There was significant dyslipidemia found in majority of the cases in connective tissue disorders. It was found that the lipid profile was deranged with increased total cholesterol and triglycerides levels after following up for a period of 3months with the initiation of corticosteroids. Conclusion: Dyslipidaemia is a contributing risk factor for atherosclerosis in CTD due to chronic inflammation.

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