Breast cancer is the second most common cancer in the world and, by far, the most frequent cancer among women with an estimated 1,67 million new cancer diagnosed in 2012 (25% of all cancers). In principle, radiation therapy is indicated in early breast cancer after breast conserving surgery or after radical mastectomy-withpositive-or-near-margin. Unfortunately, not all aforementioned indicated patients could receive immediate treatment, often due to limited radiation therapy facility. We constructed this report to investigate comprehensively, whether delayed radiation therapy for indicated-post-surgical-early breast cancer case has a significant effect to survival (either locoregional or distant metastasis-free survival). Searching was conducted on PubMed ® , Cochrane ® , and Scopus ®. After screening for titles and abstracts, we found 25 articles, 15 of which we finally included for performing full reading. From this systematic searching, we found that time to radiation is inconsistently related to locoregional survival, overall survival, and distant metastasis-free survival.

Despite technological advances in cancer treatment, especially in radiotherapy, many efforts are being made in improving cancer cell radio-sensitivity to increase therapeutic ratio and overcome cancer cell radio-resistance. In the present review, we evaluated the anticancer mechanism of Annona muricata L. (AM) leaves extract and its bioactive compounds such as annonaceous acetogenins, annomuricin, annonacin, or curcumin; and further correlated them with the potential of the mechanism to increase or to reduce cancer cells radio-sensitivity based on literature investigation. We see that AM has a promising future potential as a radio-sensitizer agent.