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Cherry leaves have been known as an antibacterial and a natural antiseptic that contain flavonoids, saponins and tannins. This research aims to prepare two formulation of cherry leaves extract and to evaluate their physical stability as an antibacterial dosage form. cherry leaves were extracted using ethanol 96% by maceration method. The extract was formulated as a hydrogel with carbomer and a water-based cream with combination of stearic acid and TEA. Physical stability was determined at cool temperature (4°C) and room temperature (± 25°C) by organoleptic, pH, homogeneity, spread, and emulsion type test (for water-based cream). The results showed that all formula of hydrogel was stable in organoleptic, homogeneity and spread test, but the pH value was on 9 which is higher than normal skin pH. Otherwise, the water-based cream was stable in organoleptic, pH and spread test, but in formula 1 showed an emulsion phase separation and formula 3 showed a non-homogeneous arrangement and visible grain after 14 days of storage. Both of the preparation was suitable to applicate cherry leaves extract in antibacterial dosage form with data of skin irritation test.

Ketoprofen is included in the Class II of Biopharmaceutical Classification System (BCS) which has low solubility. Low solubility will affect the dissolution rate and the dissolved concentration, so the absorption and bioavailability are low as well. Several studies have been conducted to improve the solubility and the dissolution of drugs from these group, such as by solid dispersion system. This study aims to determine the effect of polyvinyl alcohol (PVA) on the dissolved concentration of ketoprofen in solid dispersion and in physical mixture, and to decidethe optimum formula.Solid dispersion and physical mixture of ketoprofen - PVA were formulated with the ratio of 1:1, 1:2 and 1:4, and then compared with the standard ketoprofen. Evaluation of solid dispersion was performed by the intervention test of PVA as a matrix on the maximum wavelength of standard ketoprofen using a UV-Vis spectrophotometer and the dissolution test in artificial gastric fluid media without pepsin using a basket stirrer at pH ± 1,2, the temperature of 37 ± 0.5ºC, and device speed of 50 rpm. The sample was collected at 10, 20, 30, 45, and 60 minutes. The amount of dissolved ketoprofen was determined by a UV-Vis spectrophotometer at a wavelength of 260 nm. The results showed that there was no shifting on maximum wavelength point in both solid dispersions and physical mixtures. The dissolved ketoprofen concentration that was represented in solid dispersion was greater than in physical mixture and standard ketoprofen. The highest dissolved ketoprofen concentration was indicated in solid dispersion formula with the ratio of 1:1.

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Eel fish (Anguilla marmorata (Q.) Gaimard) on Silver eel phase contains unsaturated fatty acids such as omega-3, omega-6, EPA, DHA and vitamin A which is known to overcome various functions of body tissues. The high content of fatty acids will facilitate oxidation, making it difficult for storage and causing rancidity, thus creating a new innovation such as being formulated into cream. This study aims to formulate the silver eel (Anguilla marmorata (Q.) Gaimard.) Oil extracts in the form of cream dosage preparations and evaluates the cream dosage using physical test parameters to maintain the quality of the cream produced. This study used laboratory experimental methods and the cream formulations were made in 4 formulas, they are F0, F1, F2 and F3 with the respective concentrations of stearic acid emulsifier 6%, 8%, 10% and triethanolamine 2%, 2%, and 3.5. %, and F0 as negative controls. The result obtained test showed that the F3 positive control cream preparation met the organoleptic requirements, the result of homogeneity test was homogeneous and there were mo coarse particles, the dispersion of the cream was 6.87 cm (5-7 cm), adhesion of the cream was 4.21 seconds (>4 seconds), cream pH was 6.25 (4.5-6.5). The F3 formula gave a significant value to the characteristics of the cream