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The objective ofthis paper is to construct a class ofmodels for analyzing data in initiation-promotion (IP) studies. After the application of an initiator in animal IP studies, histochemical and/or histopathologic criteria are used to define the foci that are postulated to be the origin oftumors. Thus, the dynamics offoci growth are ofinherent interest in the study of the mechanism ofcarcinogenesis. In this paper, models to explain these dynamics are developed and can be used to differentiate among proposed mechanisms oftunor fonrnation and prmotion. Examples are given to illustate useful concepts for analyzing data from IP studies.

The objective of this paper is to construct a class of models for analyzing data in initiation-promotion (IP) studies. After the application of an initiator in animals IP studies, histochemical and/or histopathologic criteria are used to define the foci that are postulated to be the origin of tumors. Thus, the dynamics of foci growth are of inherent interest in the study of the mechanism of carcinogenesis. In this paper, models to explain these dynamics are developed and can be used to differentiate among proposed mechanisms of tumor formation and promotion. Examples are given to illustrate useful concepts for analyzing data from IP studies.

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