Introduction: Patients with long-term fixed and removable orthodontic treatment are susceptible toward an increase in oral microflora, especially Candida albicans, which can have repercussions by increasing the risk of periodontal lesions such as cariogenesis. Objective:To analyze the literature on the relationship between C. albicans and orthodontics and its epidemiology, diagnostic methods, pathogenicity and treatments. Methodology: A literature review was performed in databases with high impact such as PubMed, Scopus and Web of Science, including relevant articles from 2009 to 2022 using keywords such as: "Candida albicans", "oral candidiasis", "candidiasis", "orthodontic", "dental", "epidemiology", "diagnosis", "pathogenesis", and "treatment". Results: This fungal microorganism has a mortality rate of 40%, mainly in immunosuppressed patients. Fixed orthodontic appliances generate a significant increase for invasion by C. albicans. There are different diagnostic methods, including PCR examination, cytological smears, Gram stains, calcofluor white or fluorescent antibodies. In orthodontic patients it can be detected by clinical findings and by a decrease of HBD-3 and IL-1. Pathogenicity is directly related to host defenses, which control initial growth and inhibit subsequent tissue invasion. Treatment recommends good oral hygiene, such as manual brushing, use of chlorhexidine, ultrasonic cleaning, and the use of tablets over dentures for removable orthodontic appliances. Conclusion: Proper oral hygiene is needed during orthodontic treatment, as it is essential to reduce the presence of Candida albicans, decreasing the possibility of periodontal disease and cariogenic risk.

Introduction: Autologous platelet concentrates, have recently emerged as a possible tool to improve regenerative procedures in the medical field. Objective: To analyze the literature on autologous platelet concentrates in regenerative endodontics, such as: Platelet Rich Plasma, Platelet Rich Fibrin, PRP/PRF Vs Blood Clot as a scaffold in regenerative endodontics. Methodology: Using the keywords Regenerative Endodontic Treatment, Autologous Platelet Concentrates, Immature Teeth, Platelet-rich Fibrin, Platelet-rich Plasma, Revitalization Endodontics, the MEDLINE/PubMed and ScienceDirect databases were searched, with emphasis on the last 5 years. It was evaluated with the PRISMA and AMSTAR-2 guidelines.Results: Platelet-rich plasma releases growth factors during the first hours after placement and induction of mesenchymal stem cells. Platelet Rich Fibrin is a second-generation platelet concentrate that releases growth factors more slowly, forming a network that traps leukocytes and platelets, liquid platelet rich fibrin has a higher concentration of leukocytes, which enhances immune defense in LPS-induced inflammation. Compared to blood clot, PRP and PRF show improved healing results, reducing infection and inflammation. Conclusion:The use of autologous platelet concentrates presents a more controlled scaffold in regenerative endodontics, with successful results, such as periapical healing, root thickening and apical closure.