Our patient was a 37-year-old man with diabetes mellitus and hepatopathy as underlying diseases. Swelling, erythema and pain appeared in the left upper limb on the day before the initial examination. On examination, diffuse purpura was noted on the left upper limb, and, as it rapidly extended to the left upper trunk, emergency surgery was performed. Intraoperatively, gas-producing necrosis was observed not only in subcutaneous tissues but also from the fascia to muscle tissues, and the condition resembled clostridial gas gangrene. However, as the culturing of samples from the lesion yielded Bacillus cereus, a diagnosis of necrotizing fasciitis and myonecrosis (synergistic necrotizing cellulitis) due to B. cereus was made. While the patient developed a serious condition due to sepsis and disseminated intravascular coagulation, he could be saved by early debridement and intensive treatment with an appropriate selection of antibiotics.
The sudden onset, short duration and stereotyped features of panic attacks, and the fear aura of seizures starting at the mesial aspects of the temporal lobe, suggest common mechanisms underlying panic disorder (PD) and mesiotemporal epilepsy (MTLE). However, current consensus emphasizes the importance of differentiating the two entities based on 1) intact consciousness in panic attacks, 2) poor response to antiepileptics, and 3) unsuccessful electrophysiological attempts to demonstrate a relationship. We report two cases with a diagnosis of PD that had been partially responsive to first line treatments. During the EEG session, both patients developed panic symptoms with minimal EEG changes in response to paper bag-hyperventilation (PB-HV), and several minutes later presented a clear ictal EEG pattern associated with very different clinical symptoms, but both with strong fear content. Z-scored LORETA analysis showed increased current source densities (CSD) at the right amygdala in both subjects during the induced panic symptoms. Several areas were involved during the seizure, different in each subject. Yet, a very significant increase at the amygdala was found in both cases. The LORETA Z-scored source correlation (LSC) analysis also showed similar abnormal patterns during the panic symptoms in both patients, and marked differences during the seizure. These findings show a major role of amygdalar hyperactivity in both fear-related conditions for the two patients, and are discussed in relation to existing models of PD in general. Abnormal overactivation at mesiotemporal regions is poorly represented at the surface recordings but can be detected by the appropriate analytical techniques.
Myofibroma is an uncommon benign soft tissue disorder, which is usually congenital or present in early infancy. Myofibroma usually manifests as a single mass. When there are multiple lesions, the term myofibromatosis is used. The characteristic histopathological feature of the myofibroma is the coexistence of two distinct areas. One area mainly contains plump spindle cells with thin blunt-ended nuclei and eosinophilic cytoplasm, thus indicating myoid characteristics. The other area contains either round or polygonal cells with slightly pleomorphic, hyperchromatic nuclei or small spindle cells typically arranged around a distinct hemangiopericytoma-like vascular pattern. In the present case, the majority of the tumor was composed of the plump myoid spindle cells. This led to an initial diagnosis of a piloleiomyoma. However, the tumor cells were not immunohistochemically positive for desmin. Moreover, careful examination revealed a hemangiopericytoma-like vascular pattern characterized by the presence of high cellular areas with irregular vascular spaces. These features led to the final diagnosis of the myofibroma. It is therefore important to recognize the leiomyoma-like variants of myofibromas.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.