The aim of this study was to investigate the effect of quercetin on the motility of ejaculated human spermatozoa in asthenozoospermic cases by using different doses and exposure times. Semen samples of 94 men were incubated with quercetin at different doses and durations. Sperm motility was analysed in each group, and the results were compared. Compared to control, Quercetin improved sperm motility in each molarity and each interval except 1M. Statistically significant increase was assessed at 0.05 M after 1 hours of incubation, and 0.1 M after two hours of incubation (p<0.05). According to our results, it can be suggested that quercetin has a positive effect on sperm motility on a dose and time dependent manner. This study provides evidence for the potential use of quercetin for sperm preparation to be used in assisted reproduction techniques especially in cases of asthenozoospermia.

7 Background 8 Plant-derived natural products possess poly-pharmacologic 9 mechanisms of action with good tolerability and thus are Results 1 The signalling pathways regulated by the pleiotropic effects of 2 Actein, Withaferin A, Indole-3-Carbinol and Compound 3 Kushen were found to be projected on a set of oncogenesis 4 processes at the transcriptomic level in different breast cancer 5 subtypes (triple negative, luminal A and HER2+). Notably, 6 these compounds indirectly regulated known oncogenes in the 7 different subtypes through their associated pathways in the 8 subnetworks.9

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