Most of anti-tubercular drugs (ATD) cause various adverse drug reactions (ADRs) leading to significant morbidity which may have negative consequences on drug adherence and treatment outcome. The objectives of the study were to know the clinical profile of patients receiving ATD, to identify the pattern of ADRs caused by ATD and to know the drug utilization pattern (DUP) in different types of tuberculosis (TB). A prospective observational study was conducted among patients diagnosed with TB at DOTS center in BPKIHS from June 2017 to May 2018 and occurrence of any ADRs were detected during their monthly visit. Descriptive statistics were used to analyze the data. A total of 126 tuberculosis patients were on ATD therapy during the study period. Seventy five patients (59.5%) were male. Most of the patients (44.4%) belonged to age group 21-40 year. Pulmonary TB (66.7%) was more common than extra-pulmonary TB. Multi-drug resistant TB was detected in 4 patients (3.2%). Seventy one patients (56.3%) were found to be smear positive for acid fast bacilli. First line ATD was given to 122 patients (96.8%). Out of 126 patients, 116 (92.1%) reported occurrence of at least one ADR. A higher number of ADRs were observed in male (68.3%). Change in urine color was the most common ADR (92.9%) followed by nausea and vomiting (39.7%). Further studies covering different regions of Nepal are needed to generalize the findings.

The burden of ADRs is high globally and it accounts for considerable morbidity, mortality, and extra cost to the patients. Pharmacovigilance plays a significant role in the detection, assessment, understanding and reporting of ADRs. Objective of the study was to assess the knowledge, attitude and practice of pharmacovigilance among people working in community pharmacies in the Banke District. A prospective cross-sectional descriptive study was conducted among people working in community pharmacies in Banke district from February to March 2022 using a 20 item semi-structured questionnaire. Ethical approval was obtained from the institutional ethical review committee (501/078-079). Data were entered in Microsoft Office Excel 2010 and descriptive statistics like mean, frequency, percentage and standard deviation were calculated. Data were analyzed using SPSS-22 and data were presented as tables. Only 46 (22.89%) respondents knew the definition of pharmacovigilance. Mean knowledge score of the respondents was 2.87±2.05 out of the maximum possible score of 10. Only 40 (19.9%) respondents had knowledge score ≥50%. Out of 201, 180 (89.55%) respondents thought that reporting of adverse drug reaction will be beneficial in the future. A total of 136 (67.66%) respondents had positive attitude towards pharmacovigilance. One hundred and seventy seven (88.06%) had not seen ADR reporting form. A total of 166 (82.59%) respondents had poor practice towards pharmacovigilance. Majority of the respondents had poor knowledge, positive attitude and poor practice of pharmacovigilance. There is urgent need of educational programs on pharmacovigilance to raise awareness.