Background: Garlic has a wide range of actions, including antibacterial, antiviral, antifungal, antiprotozoal and antihelminthic actions. This antiparasitic activity has been attributed to allicin, which is the main constituent of garlic. The aim: is to evaluate the potential therapeutic and/or prophylactic effects of allicin on S. mansoni. Method: Swiss albino mice strain CD1were infected with S. mansoni cercariae and sacrificed 40 days later to acquire the adult worms. These worms were collected by perfusion and placed in RPMI medium 1640 at 37°C before transferring to RPMI media containing 0 (control), 5, 10 and 100µg/ml of allicin, where they were incubated for 48h and monitored during this time to evaluate motility and mortality rate by means of stereomicroscope. Twenty male Swiss albino mice strain CD1were divided into two groups. One group was infected with S. mansoni cercariae and treated with allicin one week post infection. The second group was (control). Results: In vitro incubation of S. mansoni adult worms with allicin, showed a statistically high significant difference in comparison with control non-treated group. All worms showed slow movement after 48 h of incubation at concentration of 100µg/ml. No effect was noticed at allicin concentrations of 10 and 5 µg/ml at the end of the experiment. Administration of allicin to the infected mice had non-significant effect on the worm burden. Conclusion: allicin was effective against adult S. mansoni worms in vitro, but with no significant effect in vivo.

An experiment was conducted to study the effect of feeding Allium Sativum (AS) at three levels 4 ,6 and 12% on serum glucose, insulin and some physiological parameters in male rats. This study included 24 adult male albino rats, with an average live body weight 140 gm. Rats were distributed into 4 groups (6 rats each). Blood samples were collected at 8 am , 4 pm and 12 pm twice after 4 then 8 weeks from the beginning of the experiment. Blood samples were centrifuged at 3000 rpm for 15 min to obtain serum. Results show that AS did not show any significant effect on serum glucose after 4 weeks, meanwhile after 8 weeks 4% AS was significantly decreased serum glucose. Serum glucose tended to be higher at 4 pm in control and most treated groups after 4 or 8 weeks from the start of the experiment. Treatment with 4 % or 6% AS for 4 weeks significantly increased serum insulin. Serum insulin were increased at 8 am after 4 weeks ,while after 8 weeks serum insulin were increased at 12 p.m. AS significantly decreased serum total protein and albumin after 4 or 8 weeks as compared with the control group .Serum cholesterol were increased after treatment with AS. .AS did not show any significant effect on serum triglycerides after 4 weeks, Meanwhile after 8 weeks AS significantly decreased serum triglycerides .After 4 weeks from the treatment 4% and 12 % AS significantly increased serum alkaline phosphatase , while after 8 weeks all groups treated with AS significantly decreased Alkaline phosphates .serum creatinine significantly decreased after treatment with AS for 4 weeks ,while after 8 weeks from the treatment 4% and 12 % AS significantly decreased serum creatinine as compared with the control group. It could be concluded that the addition of several levels of garlic in rats diet cause a several effect on some blood components under study. Feeding of diet contain garlic enhance serum insulin and glucose levels in the experimental rats. Thus we can add garlic to rat's diet by 4% or 6% from the diet to increase the performance in this animal.