Background: Problems with balance and controlling the body’s position are the most common challenges experienced by patients with multiple sclerosis (MS) who experience a high rate of falls. Objectives: The present study aimed to investigate the relationship between the severity and fear of falling (FOF) mediated by disability in patients with MS. Methods: This was a correlational study based on structural equation modeling (SEM). The statistical population consisted of all patients with MS who visited the neurology centers of hospitals in Sari, Iran, of whom 200 cases were selected as the sample using convenience sampling. The research instruments included the Falls Efficacy Scale-International (FES-I), MS Severity Scale, and the Expanded Disability Status Scale (EDSS). The data were analyzed using SEM by SPSS AMOS 25. Results: The participants included 200 patients with MS aged 33.67 ± 6.42 years. In addition, 41.5% were male, and 58.5% of female. The results of SEM indicated that the proposed model had a good fit. There was a direct and positive relationship between the severity of MS and FOF (β = 0.69; P = 0.002). Moreover, there was a direct relationship between disability and FOF (β = 0.71; P = 0.011), and between the severity of MS and disability (β = 0.63; P = 0.001) in patients with MS. The findings confirmed the relationship between the severity of MS and FOF mediated by disability in patients with MS (P < 0.001). Conclusions: Based on the results, FOF was markedly higher in patients with severer MS. Due to the consequences of FOF, counseling training programs should be offered to patients with MS who visit medical centers to improve their health and level of activity and mitigate their FOF.

Background: Fear of falling (FoF) is a permanent concern and may limit daily activities and diminish confidence in balance abilities leading to muscular deterioration, a sedentary lifestyle, and reduced quality of life. The present study aimed to investigate the relationship between multiple sclerosis severity and FoF with mediating roles of disability, cognitive factors, and physical factors among patients with multiple sclerosis (MS). Methods: This research was a correlational study based on path analysis. The statistical population consisted of all patients with MS who visited the neurology centers of hospitals in Sari, Iran. A total of 200 MS patients were selected as the sample using multistage random sampling. Two hospitals were selected from the hospitals of Sari city and the research sample was selected from the neurology centers of these hospitals. The research instruments included the falls efficacy scale-international, the MS severity scale, the expanded disability status scale, the cognitive factors questionnaire, and the MOS 36-item short-form health survey. The data were analyzed by structural equation modeling in AMOS and SPSS software, version 25. Results: The results of structural equation modeling demonstrated that the proposed model fitted the data. FoF had positive significant relationships with MS severity and disability. MS severity and FoF had negative significant relationships with physical factors (P<0.01). The direct relationship between MS severity and cognitive factors was insignificant and excluded from the model. The study findings confirmed the relationship between MS severity and FoF mediated by disability and physical factors in patients with MS (P<0.01). Conclusion: The frequency of FoF was much higher among patients with higher MS severity. Considering the consequences of the FoF among patients with MS, it is recommended that consultation services be provided to patients with MS at healthcare centers to improve their health and activity and reduce their FoF.