Continuous Positive Airway Pressure (CPAP) ventilation remains a mainstay treatment for different respiratory disorders. Good pressure stability and pressure reduction during exhalation are of major importance condition to ensure the clinical efficacy and comfort of CPAP therapy.  Obstructive Sleep Apnea (OSA) and today coronavirus (COVID-19) are the main two diseases mitigated by the CPAP. This paper introduced a systematic review of the CPAP design in terms of the hardware design, Simulation-based CPAP system, control algorithm, and the measured performance. The accuracy is used as measurement of performance and calculated from the pressure value. The accuracy was compared to the predefined U.S. Food and Drug Administration (FDA)-based threshold value in which it considers this value as a reference. The results related to the modern CPAP devices introduced in this study to explain the accuracy of experimental CPAP. These were compared with a commercial CPAP devices. Also, it was revealed how the results coincide with the error ratio defined by the FDA as an evaluation measurement. The FDA error ratio determines the performance of the optimized CPAP device. This work is the first review that presented the knowledge about engineering design of the CPAP system, so it will be the first in the literature.

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