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Different automated decision support systems based on artificial neural network (ANN) have been widely proposed for the detection of heart disease in previous studies. However, most of these techniques focus on the preprocessing of features only. In this paper, we focus on both, i.e., refinement of features and elimination of the problems posed by the predictive model, i.e., the problems of underfitting and overfitting. By avoiding the model from overfitting and underfitting, it can show good performance on both the datasets, i.e., training data and testing data. Inappropriate network configuration and irrelevant features often result in overfitting the training data. To eliminate irrelevant features, we propose to use χ 2 statistical model while the optimally configured deep neural network (DNN) is searched by using exhaustive search strategy. The strength of the proposed hybrid model named χ 2-DNN is evaluated by comparing its performance with conventional ANN and DNN models, another state of the art machine learning models and previously reported methods for heart disease prediction. The proposed model achieves the prediction accuracy of 93.33%. The obtained results are promising compared to the previously reported methods. The findings of the study suggest that the proposed diagnostic system can be used by physicians to accurately predict heart disease. INDEX TERMS Deep neural network, heart disease, hyperparameters optimization, overfitting, underfitting.

One of the leading causes of deaths around the globe is heart disease. Heart is an organ that is responsible for the supply of blood to each part of the body. Coronary artery disease (CAD) and chronic heart failure (CHF) often lead to heart attack. Traditional medical procedures (angiography) for the diagnosis of heart disease have higher cost as well as serious health concerns. Therefore, researchers have developed various automated diagnostic systems based on machine learning (ML) and data mining techniques. ML-based automated diagnostic systems provide an affordable, efficient, and reliable solutions for heart disease detection. Various ML, data mining methods, and data modalities have been utilized in the past. Many previous review papers have presented systematic reviews based on one type of data modality. This study, therefore, targets systematic review of automated diagnosis for heart disease prediction based on different types of modalities, i.e., clinical feature-based data modality, images, and ECG. Moreover, this paper critically evaluates the previous methods and presents the limitations in these methods. Finally, the article provides some future research directions in the domain of automated heart disease detection based on machine learning and multiple of data modalities.

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Parkinson’s disease (PD) is one of the most common and serious neurological diseases. Impairments in voice have been reported to be the early biomarkers of the disease. Hence, development of PD diagnostic tool will help early diagnosis of the disease. Additionally, intelligent system developed for binary classification of PD and healthy controls can also be exploited in future as an instrument for prodromal diagnosis. Notably, patients with rapid eye movement (REM) sleep behaviour disorder (RBD) represent a good model as they develop PD with a high probability. It has been shown that slight speech and voice impairment may be a sensitive marker of preclinical PD. In this study, we propose PD detection by extracting cepstral features from the voice signals collected from people with PD and healthy subjects. To classify the extracted features, we propose to use dimensionality reduction through linear discriminant analysis and classification through support vector machine. In order to validate the effectiveness of the proposed method, we also developed ten different machine learning models. It was observed that the proposed method yield area under the curve (AUC) of 88%, sensitivity of 73.33%, and specificity of 84%. Moreover, the proposed intelligent system was simulated using publicly available multiple types of voice database. Additionally, the data were collected from patients under on-state. The obtained results on the public database are promising compared to the previously published work.