This is a retrospective analysis of whether the 8th edition American Joint Committee on Cancer (AJCC) was a significant improvement over the 7th AJCC distal extrahepatic cholangiocarcinoma classification. Methods: In total, 111 patients who underwent curative resection of mid-distal bile duct cancer from 2002 to 2019 were included. Cases were re-classified into 7th and 8th AJCC as well as clinicopathological univariate and multivariate, and Kaplan-Meier survival curve and log rank were calculated using R software. Results: In patient characteristics, pancreaticoduodenectomy/pylorus preserving pancreaticoduodenectomy had better survival than segmental resection. Only lymphovascular invasion was found to be significant (hazard ratio 2.01, p = 0.039) among all clinicopathological variables. The 8th edition AJCC Kaplan Meier survival curve showed an inability to properly segregate stage I and IIA, while there was a large difference in survival probability between IIA and IIB. Conclusions: The 8th distal AJCC classification did resolve the anatomical issue with the T stage, as T1 and T3 showed improvement over the 7th AJCC, and the N stage division of the N1 and N2 category was found to be justified, with poorer survival in N2 than N1. Meanwhile, in TMN staging, the 8th AJCC was able differentiate between early stage (I and IIA) and late stage (IIB and III) to better explain the patient prognosis.

Background: Pancreatic cancer is a deadly disease, mainly because of early metastasis. Predicting prognosis of pancreatic cancer patients will increase the survival rate of cancer. Metabolic Tumor Volume (MTV) and Circulating Tumor Cells (CTC) are notable prognostic factors and biomarkers of tumors. But no study has been done about the association of CTC and MTV in pancreatic cancer. Methods: This study enrolled patients with PDAC who were treated between July 2018 and December 2021 at Gangnam Severance Hospital. DIS-μChip was used to isolate CTCs from the blood of pancreatic cancer patients. The association between CTC and MTV was evaluated using the Mann Whitney U test and Pearson's correlation analysis. Results: Metabolic tumor volume (MTV) and CTC count are correlated in the study (p < 0.001). Median Recurrence Free Survival (RFS) was 6.1 months versus 8.4 months in patients with higher CTC counts (p < 0.05). Radiomic features of PET CT (gray level non uniformity, entropy, coarseness, joint energy, maximum probability) were also identified to have a relationship with the CTC count. In the multivariate analysis, CTC independently predicted RFS after curative resection of pancreatic cancer. This study showed that CTC counts are higher in patients with larger metabolic tumor volume and heterogenous cancer. Both the CTC counts and tumor volume were strong predictors of RFS after curative resection. Conclusions: These findings identify the relationship between MTV and CTC. Metabolic tumor volume measurements may provide complementary findings of CTC counts and tumor heterogenous informations. Used together or alternatively, they can be used to anticipate prognosis of pancreatic cancer.