Weaver syndrome (WVS) (OMIM #277590) is an overgrowth disorder first described in two boys in 1974, and characterized by prenatal and/or postnatal overgrowth, accelerated osseous maturation, musculoskeletal abnormalities, camptodactyly, variable intellectual disability, and characteristic craniofacial features (macrocephaly, large bifrontal diameter, flattened occiput, long philtrum, round face in infancy, retrognathia, prominent chin crease, large ears, strabismus, hypertelorism, epicanthal folds, down slanting palpebral fissures and depressed nasal bridge) (Cyrus et al., 2019;Weaver et al., 1974). WVS