Background: The pattern of dyslipidemia varies among the patients of type 2 of diabetes mellitus. Objective: The purpose of the present study was to observe gender difference of lipid abnormalities in type-2 Diabetes Mellitus patients. Methodology: This cross sectional comparative study was conducted in the OPD of Department of medicine at BIRDEM, Dhaka

Background: Type 2 Diabetes Mellitus (T2DM) and thyroid disorder are common endocrine disorders that affect major population worldwide. Subclinical hypothyroidism is common among T2DM.Objectives: To observe thyroid stimulating hormone (TSH), total thyroxine (TT4), free thyroxine (FT4), total triiodothyronine (TT3), free triiodothyronine (FT3) levels in newly diagnosed T2DM.Methods: This cross sectional study was conducted from July 2014 to June 2015. For this, 50 newly diagnosed T2DM patients aged 30 to 50 years of both sexes were enrolled from the Out Patient Department of Endocrinology, Rangpur Medical College and Diabetic Association, Rangpur. Fifty age matched non-diabetic healthy subjects of both sexes constituted control. Serum TSH, TT4 , FT4, TT3, FT3 levels were estimated to observe thyroid function. All these hormones were estimated by ELISA method. For statistical analysis independent sample “t” test was performed.Results: Serum TSH was significantly higher (p<0.001) and serum TT4, FT4, FT3 levels were significantly lower (p<0.001) in T2DM compared to control. Eight (16%) of T2DM were hypothyroid.Conclusion: From this study it can be concluded that altered thyroid status leading to hypothyroidism may be associated with T2DM.Bangladesh Soc Physiol. 2017, December; 12(2): 61-64

Background: Overweight and obesity has been announced as a global epidemic by The World Health Organization. These conditions have strong associations with renal function impairment. Objectives: To evaluate the estimated glomerular filtration rate (eGFR) in obese male adults and to observe the correlation of eGFR with body mass index (BMI). Methods: This cross-sectional analytical study was conducted at the Department of Physiology, Rangpur Medical College, Rangpur. After briefing about objectives, adult males who met the inclusion and exclusion criteria were enrolled in the study by consensus. The study involved 60 people who were divided into two groups: apparently healthy adult males of average weight (Group A) and apparently healthy adult males who were obese (Group B). The subjects were selected from different districts of the city of Rangpur. Their body mass index & serum creatinine were measured. eGFR was calculated by Cockcroft-Gault equation using serum creatinine. For statistical analysis, unpaired t-test and Pearson’s correlation coefficient test were performed as applicable by computer-based SPSS–25.0 for windows. Regarding the interpretation of results, p≤0.05 was accepted as significant. Results: The mean of estimated glomerular filtration rate was significantly (p≤ 0.001) lower in obese male adults than in normal-weight male adults. This study also found a highly significant (p≤0.05) negative correlation of eGFR (r = -0.317) with body mass index. Conclusion: eGFR is reduced in obese male adults, and it is negatively correlated with BMI. Regular body mass index screening is recommended as an easy and effective means of assessing body weight. J Rang Med Col. March 2023; Vol. 8, No. 2:27-32

Background: Sedentary lifestyle is an issue of great concern because of its deleterious health implication. It is associated with limited physical activity. Regular physical activity with good physical fitness are widely accepted as factors that reduce all cause of mortality and improve number of health outcome. Objective: To assess the cardiovascular sympathetic nerve function status by the cold pressor test in healthy adult male sedentary workers. Methods: This cross-sectional analytical study was conducted from January 2019 to December 2019 in the Department of Physiology, Rangpur Medical College, Rangpur. After obtaining permission, a total 60 subjects who were met the inclusion criteria was enrolled in the study after briefing them objectives of the study. Among them 30 were healthy adult male heavy workers (Group-A) and 30 were healthy adult male sedentary workers (Group-B). The basal systolic and diastolic blood pressure was recorded in resting condition. The evaluation of sympathetic nerve functions in selected individuals was done by cold pressor test. The individuals were selected from different areas of Rangpur district. For statistical analysis unpaired t-test was performed by computer-based software SPSS-23.0 version for windows. Results: The resting systolic and diastolic blood pressure are non-significant in selected individuals. Diastolic blood pressure response by cold pressor test was significantly lower in sedentary workers. (p< 0.05). Conclusion: The study thus concluded that decreased diastolic blood pressure response by cold pressor test in sedentary individuals indicate impairment of the sympathetic nerve function. J Rang Med Col. March 2023; Vol. 8, No. 2:59-64

Background: Workers in environment with cotton dust exposure are at risk of development of occupational pulmonary functional disorder.Objectives: To observe the effects of cotton dust exposure on FVC, FEV1, FEV1/FVC% in male cotton dust worker.Methods: This cross-sectional study was carried out in the department of physiology, Rangpur Medical College, Rangpur from 2014’july to 2015’July. Total 25 apparently healthy non-smoker male workers aged 20-40 years, exposed to cotton dust for at least 6 months, were selected from different fabric weaving and cotton ginning factories of Rangpur district. Twenty five age & BMI matched apparently healthy male subjects, not exposed to cotton dusts were taken as control. FVC, FEV1 and FEV1 /FVC% of all subjects were recorded by using a digital spirometer. For statistical analysis, unpaired‘t’-test was performed.Results: The mean percentage of predicted value of FVC, FEV1 were significantly lower (p<0.001) in cotton dust exposed workers (CD-EW) than those of control. The mean percentage of predicted value of FEV1 / FVC% in CD-EW is slightly decreased compared to control but it was not statistically significant.Conclusions: From the result of this study it can be concluded that cotton dust (CD) may have harmful effects on some pulmonary function.Bangladesh Soc Physiol. 2016, June; 11(1): 35-38