Phosphate glass dissolution can be tailored via compositional and subsequent structural changes, which is of interest for biomedical applications such as therapeutic ion delivery. Here, solid-state 31P nuclear magnetic resonance...

To facilitate the efficient use of phosphate-based glasses in various biomedical applications, it is essential to understand the effects of ion-releasing in the living body. In this work, the ion-releasing behavior of silicophosphate glass, designed as a supply source of silicate and phosphate ions that are effective for bone formation, was investigated. Two types of P 2 O 5 -SiO 2 -CaO-Na 2 O glasses containing 45-50 mol% of P 2 O 5 with both four-and six-fold coordinated silicon structures were prepared. The glass with ~50 mol% of P 2 O 5 content had a higher proportion of six-fold coordinated silicon structure, and it showed a lower ionic release to a simulated body fluid than that with ~45 mol% P 2 O 5 content. The release of the therapeutic ions from the silicophosphate glass can be effectively controlled by choosing their composition.