There is increasing evidence about the effectiveness of electrochemotherapy (ECT) in the treatment of basal cell carcinomas in the head and neck region, although its role in the management of eyelid-periocular skin tumors has to be clarified. The aim of the present study is to evaluate the results of ECT in the treatment of locally advanced primary and recurrent eyelid-periocular skin basal cell carcinomas. Twelve patients with basal cell carcinoma involving the eyelid-periocular skin region were treated with ECT. Three patients had locally advanced primary tumors, while 9 patients had recurrent tumors. All treatments were performed according to the ESOPE guidelines, using Cliniporator TM device. All patients received bleomycin based ECT. The route of administration was intratumoral in 3 patients and intravenous in 9 patients. Tumor response was evaluated using the RECIST 1.1. criteria. ECT resulted in complete response of the periocular skin tumors in all patients. Lower eyelid ectropion was developed in 3 patients which had to be corrected surgically. ECT can be used effectively in the treatment of locally advanced or recurrent basal cell carcinomas in the eyelid-periocular skin region. Excellent tumor control can be achieved with good functional and cosmetic results without systemic adverse events with short interval follow-up.

Squamous cell papilloma (SCP) is generally a human papillomavirus (HPV) induced exophytic or endophytic proliferation on the surface of the skin, oral cavity, larynx, esophagus, cervix, vagina, and anal canal. The endophytic type SCP can cause differential diagnostic difficulties with keratoacanthoma, inverted follicular keratosis, and squamous cell carcinoma; however, these lesions are not associated with HPV infection. The authors present a female patient who noticed an extremely rapidly growing tumor destructing the left lower eyelid. The histological analysis of the biopsy sample revealed a virus-induced squamoproliferative lesion. The eyelid affected was completely removed, and the histological examination resulted in a HPV induced endophytic squamous cell papilloma. The tarsus and the conjunctiva were replaced by a chondromucosal graft harvested from the nasal septum, while the skin defect could be closed directly. Restoration of the eyelid function has been achieved with satisfying functional and cosmetic results.

A 72-year-old male patient was referred to our outpatient clinic with a painful left eye protrusion accompanied by marked conjunctival chemosis and external ophthalmoplegia being progressed despite topical and oral antibiotic therapy. He developed ocular symptoms 9 days after receiving his second SARS-CoV-2 vaccine (VeroCell). Of note, in previous history, 2 weeks after the first dose of the COVID-19 vaccine, he also developed a life-threatening laryngeal oedema treated at an emergency care unit. MRI of the orbit excluded pansinusitis as possible origin of the orbital cellulitis, and repeated COVID-19 antigen and antibody PCR tests were negative during his hospitalization. On the next day after his admittance, parenteral dexamethasone 250 mg/die treatment was commenced resulting in a quick and complete resolution of the symptoms. Due to the facts regarding this case, such as the temporal coincidence and the lack of respective comorbidity, there might be a causative relationship between the vaccination and the presented orbital cellulitis. To the best of our knowledge, this is the first report on orbital cellulitis as a possible ocular adverse event following COVID-19 vaccination.

A strongly developing sector of the small scale photovoltaic (PV) systems are the urban applications. There are a lot of compromise where and how to set up these systems in a crowded city. A lot of limiting constraints such as roof space available, shadow effects, orientation of the roof, etc. Because of the disadvantageous ideal circumstances appear the multi-tilted PV systems, where some strings or some element of the string is oriented in different directions. In this paper we give the basics of the energy yield calculation and also compare these calculations to real measurements.

Egy 72 éves férfi esetét ismertetjük, akit bal orbitára terjedő ismeretlen eredetű, antibiotikumterápiára nem reagáló cellulitis miatt vettünk fel klinikánkra. A szemészeti tünetek 9 nappal a második, inaktivált COVID-19-oltás (VeroCell – China National Pharmaceutical Group Co. Ltd.) beadását követően jelentkeztek, először a szem „vibrálásával”, majd kidülledésével. Kórelőzményből kiemelendő, hogy az első vakcina beadása után két héttel gégeödéma alakult ki a betegnél, amely sürgősségi ellátás keretében intravénás szteroidkezelést igényelt. A fentiek ellenére a második, ugyanolyan vakcina beadását nem tartották kontraindikáltnak. A beteg felvételekor a bal szemen jelentős protrúziót, minden irányban korlátozott szemmozgásokat és kifejezett kötőhártya-chemosist találtunk, ugyanakkor a fül-orr-gégészeti konzílium az orrmelléküreg-eredetű fertőzést kizárta. A korábban megkezdett parenterális antibiotikumterápia hatástalansága miatt a harmadik napon intravénás szteroidterápiát indítottunk, amely után gyors javulást tapasztaltunk, és néhány nappal később a beteget tünetmentesen emittáltuk. A kórelőzményben nem szerepelt COVID-19-fertőzés, és a beteg bennfekvése során többször ismételt antigén gyorsteszt, illetve PCR-teszt sem aktív, sem lezajlott fertőzést nem támasztott alá. Mindezek alapján a leírt szemészeti kórkép nagy valószínűséggel tartható a COVID-19-oltás szövődményének. Tudomásunk szerint eddig a szakirodalom nem írt le orbita cellulitist oltási szövődményként.