tests. On these 33 patients, ICT and CFF were applied. 35 healthy subjects served as controls for the ICT and CFF. RESULTS: Taking > 9 lures as positive ICT according to receiver operator characteristic (ROC) curve, the sensitivity, specificity, PPV and NPV were 90.9%, 37.1%, 57.6%, 81.3% respectively. Cirrhotics with MHE had significantly higher lures (22 ± 7.8 vs 11 ± 5.6, p < 0.001) or (56% vs 28%) and lower target response (90% vs 97%) compared with controls. For CFF taking < 37 Hz as cut-off, the sensitivity, specificity, PPV and NPV were 57.5%, 94.3%, 90.5% and 70.2%. We also found that CFF is less time consuming as compare to ICT. CONCLUSION: ICT and CFF are useful tools to assess MHE. CFF to be less time to consume, less sensitive but more specific than ICT.
INTRODUCTIONHepatic encephalopathy (HE) is a complex neuropsychiatric syndrome present in patients with chronic or acute liver disease after exclusion of other brain diseases. According to recent guidelines (AASLD/EASL 2014), hepatic encephalopathy is a brain dysfunction caused by liver insufficiency and/or portosystemic shunting; it manifests as a wide spectrum of neurological or psychiatric abnormalities ranging from subclinical alterations to coma [1] . Patients with cirrhosis with normal neurologic and mental examination can present minimal forms of HE, showing intellectual function impairment that cannot be detected through general clinical examination but can be unveiled using specific neuropsychologic and neurophysiologic tests [2] . MHE has significant negative impact on
Respiratory and reproductive disorders in dairy animals due to various etiological agents have led to significant economic losses to dairy industry. These losses are due to abortions, metritis, retention of placenta, repeat breeding, death of animals, loss of production and trade restrictions etc. The objectives of this cross-sectional study were to detect the seroprevalence of infectious bovine rhinotracheitis (IBR, BHV-1) in dairy animals of western parts of Uttar Pradesh, India. Anti BHV-1 antibodies were measured using a commercial ELISA kit (SYANOVIR® IBR-Ab). Blood samples were collected from a total of 134 animals of different age, gender from 8 districts. Overall individual seroprevalence was 32.84%. The study revealed that BHV-1 is comparatively more widespread in cattle (46.51%) than buffalo (35.28%). Comparison of different sex groups of animals revealed that the higher numbers of infected animals were identified in male (48.00%) than female (29.35%). The seropositivity of IBR increased with age of animals. The highest prevalence of IBR (66.67%) was observed in animals aged more than 8 years. As vaccination against IBR is not practiced in the region and higher percent positivity (>20%) in all age group of animals indicated the natural circulation of BHV-1 virus in the population. Because of less awareness on the vaccination of animals against this virus, the disease may spread rapidly. The results of present study also indicate that strict monitoring and surveillance of IBR is need of today to protect the animals from infection and further spread.
Aluminium phosphide ingestion is the most common agricultural poisoning in suburban and rural India and with a high mortality rate. Among survivors of acute poisoning there are recent sporadic reports of esophageal complications such as esophageal strictures and tracheo-esophageal fistula. The present study was carried out to determine the incidence, natural history, and treatment outcome of local esophageal complications in survivors of aluminium phosphide poisoning with complaints of dysphagia. All confirmed cases of poisoning with aluminium phosphide ingestion were admitted in Hamidia Hospital, Gandhi Medical College, Bhopal, Madhya Pradesh, India, from October 2007 to October 2008. Survivors with complaints of dysphagia underwent a barium study and upper gastrointestinal endoscopy to determine site and nature of esophageal complications. All cases of strictures were treated with fluoroscopy-guided Savary-Gilliard bougie dilation, and patients with tracheo-esophageal fistula underwent surgery. Of 104 confirmed cases, 31 survived. Ten survivors with dysphagia were found to have single short-segment esophageal stricture and two patients with odynophagia and swallow-cough sequence had tracheo-esophageal fistula. All cases of esophageal strictures responded successfully to Savary-Gilliard dilation in six to ten sessions without any major complications. Patients with tracheo-esophageal fistula were treated successfully via surgery. Nearly one-third of survivors of aluminium phosphide ingestion developed esophageal complications. Hence, we conclude that all survivors of aluminium phosphide poisoning must undergo barium swallow and endoscopic examination for early detection of esophageal complications. Prevention of esophageal complications after aluminium phosphide ingestion needs to be given adequate attention because tracheo-esophageal fistula and esophageal stricture are associated with high morbidity. When one finds esophageal stricture or fistula, the possibility of aluminium phosphide ingestion should always be considered.
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