No abstract

Tri-C is a Chromosome Conformation Capture (3C) approach, which can very efficiently identify multiway chromatin interactions at individual alleles with selected viewpoints of interest at high resolution.Tri-C allows for multiplexing both viewpoints and samples. As identification of multi-way interactions relies on Illumina sequencing, data can be generated at great depth and PCR duplicates (based on identical sonication ends) can accurately be removed, allowing for high-throughput, quantitative analysis of multi-way chromatin interactions.