Salvia officinalis L. is an important medicinal and aromatic plant species belonging to Lamiaceae family, largely used in folk medicine and in culinary. This plant species is growing mainly wild in the mountain areas of Albania where the population's essential oils composition is affected by environmental factors and weather conditions. The aim of the present study is to provide data on the EO composition of the S. officinalis in Southern Albania, and on the influence of climatic conditions on foreground temperature and precipitations in a selected location on the variation of the EO components. The essential oils were extracted by hydro-distillation and analyzed by gas chromatography (GC-FID). Qualitative and quantitative variation in composition of essential oil was analyzed on yearly basis for five consecutive years. In total, 20 main compounds were identified representing 95.1% to 98.9% of the total EO. Monoterpenes were found to be the main group of components ranging from 87.8% to 95.5% of total EO with the oxygenated monoterpenes as the most abundant compounds. The chemical profile of S. officinalis grown wild in mountain area in Southern Albania was alpha-Thujone (29.9%) > Camphor (21.7%) > Cineole (12.1 %) > Camphene (7.9 %) > beta-Thujone (5.4%) > alpha-Pinene (4.6%) > alfa-Humulene (2.6%) > beta-Caryophyllene (2.5%). The temperature was positively correlated with, sesquiterpenes and negatively correlated with bicyclic monoterpenes, while the opposite was observed for precipitation. The ordination analysis results PCA explained 93% of total variance, camphene, camphor, alpha-pinene, cineole and beta-thujone were the most variable components among analyzed years.