Numerous studies have demonstrated that people high on attachment insecurity are more likely to report depressive symptoms as compared to those low on insecurity (secures). These findings suggest that enhancing one's sense of attachment security could help relieve depressive symptoms. One promising technique for increasing attachment security that has received relatively little attention as a therapeutic intervention is attachment security priming. Compared with other interventions, security priming is easier and takes less time to administer. The current studies examined if priming techniques used to increase attachment security could reduce depressive symptoms in an adolescent and emerging adults samples. In Study 1, depressive symptoms were assessed before exposure to either attachment security or neutral primes and then re-assessed one week later. Results revealed that participants who were exposed to the security primes reported a greater decrease in depressive symptoms than the control group. In Study 2, adolescents who were repeatedly exposed over two weeks to security primes showed lower depression symptoms than participants exposed to neutral primes. Overall, our findings provide initial support to the idea that attachment security priming can be a useful method to help decrease depressive symptoms.
Purpose Obesity is a growing public health concern now reaching epidemic status worldwide for children and adults due to multiple problems impacting on energy intake and expenditure with influences on human reproduction and infertility. A positive family history and genetic factors are known to play a role in obesity by influencing eating behavior, weight and level of physical activity and also contributing to human reproduction and infertility. Recent advances in genetic technology have led to discoveries of new susceptibility genes for obesity and causation of infertility. The goal of our study was to provide an update of clinically relevant candidate and known genes for obesity and infertility using high resolution chromosome ideograms with gene symbols and tabular form. Methods We used computer-based internet websites including PubMed to search for combinations of key words such as obesity, body mass index, infertility, reproduction, azoospermia, endometriosis, diminished ovarian reserve, estrogen along with genetics, gene mutations or variants to identify evidence for development of a master list of recognized obesity genes in humans and those involved with infertility and reproduction. Gene symbols for known and candidate genes for obesity were plotted on high resolution chromosome ideograms at the 850 band level. Both infertility and obesity genes were listed separately in alphabetical order in tabular form and those highlighted when involved with both conditions. Results By searching the medical literature and computer generated websites for key words, we found documented evidence for 370 genes playing a role in obesity and 153 genes for human reproduction or infertility. The obesity genes primarily affected common pathways in lipid metabolism, deposition or transport, eating behavior and food selection, physical activity or energy expenditure. Twenty-one of the obesity genes were also associated with human infertility and reproduction. Gene symbols were plotted on high resolution ideograms and their name, precise chromosome band location and description were summarized in tabular form. Conclusions Meaningful correlations in the obesity phenotype and associated human infertility and reproduction are represented with the location of genes on chromosome ideograms along with description of the gene and position in tabular form. These high resolution chromosome ideograms and tables will be useful in genetic awareness and counseling, diagnosis and treatment to improve clinical outcomes.
The location of gene symbols plotted on high resolution chromosome ideograms forms a conceptualized image of the distribution of human reproduction genes. The updated master list can be used to promote better awareness of genetics of reproduction and related infertility and advance discoveries on genetic causes and disease mechanisms.
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