The ABCD(3)-I score had a higher predictive value than the ABCD(2) score for assessing the risk of early stroke after transient ischemic attack in a Chinese population.

B vitamin supplementation for homocysteine reduction significantly reduced stroke events, especially in subjects with certain characteristics who received appropriate intervention measures.

Background Marked functional impairment has been reported by patients with Post- Treatment Lyme Disease Syndrome (PTLDS), but the clinical features which contribute most strongly to the impaired health status remain unknown. Methods Enrolled patients had a well-documented history of Lyme disease, prior treatment with at least 3 weeks with IV ceftriaxone, a positive IgG Western blot, and objective problems with memory. An index score to capture aggregate cognitive functioning, Short-Form 36 (SF-36) physical and mental component scores, and scores on other clinical and demographic measures were examined. Multiple linear regressions were performed to determine significant predictors of perceptions of impaired life functioning as delineated by the SF-36. Results Fatigue was the most important contributor to perceived impairments in overall physical functioning and fatigue and depression significantly predicted perceived impairments in overall mental functioning. Conclusions Because fatigue and depression contribute prominently to reports of impaired physical and mental functioning among patients with PTLDS, clinicians should assess carefully for these symptoms and consider targeting these symptoms in the selection of treatment interventions. Future controlled studies should examine the effectiveness of such agents for patients with PTLDS

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