No abstract

Objective: 12,13-Dihydroxy-9Z-octadecenoic acid (12,13-diHOME) is a lipokine secreted from brown adipose tissue, and it has positive effects on dyslipidemia.Acute exercise has been shown to lead to an increase in its secretion. In this study, it was aimed to investigate the relationship of 12,13-diHOME with obesity, exercise and dyslipidaemia for the first time in the adolescent age group.Design: Prospective study.Patients: Twenty-eight male adolescents with obesity and the same number of agematched healthy normal-weight male controls.Measurements: Fasting serum glucose, insulin, lipid and 12,13-diHOME levels were measured. Cardiopulmonary exercise testing was performed in all subjects using a stress test treadmill. Peak oxygen consumption (peak VO2) and anaerobic threshold heart rate (ATHR) were measured.Results: Adolescents with obesity had lower 12,13-diHOME levels than normalweight adolescents both before and after acute exercise (p = .025 and p = .019, respectively), and after acute exercise, 12,13-diHOME levels significantly increased in both groups (p = .001 for both). 12,13-diHOME levels negatively correlated with triglyceride, total cholesterol, LDL-C, and positively correlated with HDL-C. Also, peak VO 2 and ATHR levels showed positive correlation with 12,13-diHOME levels.Conclusion: 12,13-diHOME levels were found to be lower in adolescents with obesity than normal-weight adolescents and increased with acute exercise. Also, the close relationship of this molecule with dyslipidaemia in addition to that with obesity suggests that it has an important role in the pathophysiology of these disorders.Further molecular studies will further elucidate the role of 12,13-diHOME in obesity and dyslipidaemia.

BackgroundFever and the fear of febrile seizure risk in parents are a common reason that lead parents to seek care in childhood emergency departments. The most frequently seen periodic fever syndromes in Turkey are periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis (PFAPA) syndrome and familial Mediterranean fever (FMF). There is lack of data regarding the frequency of febrile seizures in periodic fever syndromes.ObjectivesTo document the frequency of febrile seizure in patients with Familial Mediterranean Fever and PFAPA syndrome.MethodsPatients with FMF and PFAPA, who were diagnosed according to Turkish paediatric FMF diagnostic criteria and Marshall criteria, were enrolled to the study. Past medical history of all subjects from postnatal six months to 6 years of age were assessed in terms of febrile seizure. Clinical, demographic and laboratory data of both patient groups were obtained from patient files. The frequency of febrile seizure in both disease groups was compared with the prevalence in healthy children of a previous Turkish study.ResultsA total of 417 FMF and 157 PFAPA subjects were recruited to the study with a female frequency of 49.9% and 42.8%, respectively. The mean age of the FMF and PFAPA patients at study time was 12.4±4.5 years and 5.3±2.1 years, respectively. The mean age at disease onset was 5.1±3.8 (IQR: 2–7) years in FMF group, whereas it was 21±16.5 months (IQR: 10–30) in PFAPA group. The frequency of febrile seizure in FMF and PFAPA syndrome was similar (8.4% versus 8.6%, p>0.05). Among the subjects with febrile seizure, 42.9% (n=15) in FMF group and 30.8% (n=4) in PFAPA group underwent electroencephalography. The EEG result of all subjects were reported to be normal. While 8 subjects with febrile seizure (22.9%) in FMF group required anticonvulsant therapy, 2 patients (15.4%) in PFAPA group used anticonvulsant treatment. Among the PFAPA subjects with febrile seizure (n=13), 53.9% (n=7) underwent tonsillectomy. Thereafter, 85.7% (n=6) of the patients with tonsillectomy never experienced a febrile seizure.Both the FMF and PFAPA syndrome group were found to have a higher frequency of febrile seizure compared with the healthy subjects of the previous Turkish study (FMF versus healthy children: 8.4% versus 3.2%) (PFAPA syndrome versus healthy children: 8.6% versus 3.2%); and this was statistically significant (p<0.001). However, the frequency of febrile seizure in FMF did not differ from the patients with PFAPA syndrome (8.4% versus 8.6%, p>0.05).ConclusionsCompared to the healthy children, the frequency of febrile seizure in FMF and PFAPA syndrome was significantly increased. The recurrent fever, which is the main shared manifestation of these two diseases, is possibly a trigger for febrile seizure. This increased frequency of febrile seizure in both periodic syndrome seems to be a result of recurrent fever, other than a neurologic involvement of the FMF itself.References[1] Barut K, Sahin S, Adrovic A, Sinoplu AB, Yucel G, Pamuk G, et al. Familial Mediterranean fever in c...