Progressive loss of mass and function of beta cells are important pathophysiological features of diabetes. There by the best therapy and potential cure for both T1DM and T2DM is to replace orregenerate the insulin-producing pancreatic beta cell. Restoration of the functional beta cell mass is therefore expected to be a key aim of diabetes therapy. In this context, researchers from Harvard Stem Cell Institute (HSBI) recently found a new hormone and named it betatrophin, which could increase the quantity of insulin producing betacells in mice [1]. Before discovery of betatrophin by HSBI, different research teams have named this hormone differently according to its different functions: Including angiotensin amyloid 8(ANGPTL8), lipoprotein lipase