Objective: The aim of our study was to determine the most common cause of liver cirrhosis in district Buner.   Methodology: This was retrospective cross-sectional study. Data was collected from patient’s record register from January 2016 till December 2018. A total of 203 patients were included in this study. Data was collected and entered and analyzed in IBM SPSS 23.   Results: Out of 203 cases, 135(66.5%) were males and 68 (33.5%) were females. The main cause of cirrhosis was HCV (n=163, 80.3%) and HBV (n=27, 13.3%). Cryptogenic cirrhosis occurred in 9 cases (4.4%) while others were only 1% (n=2). HCV was more positive in males (n=108, 66.25%) than in females (n=55, 33.7%), this was statistically significant with a p value .022.   Conclusion: We conclude with our study that HCV is major cause of Liver Cirrhosis in our patients. HCV is more common in males than in females. Cirrhosis occurs most commonly in 4th, 5th and 6th decades of life after being infected with HBV and HCV.   Keywords: Liver cirrhosis, Hepatitis C virus, Hepatitis B virus, Pakistan.