Objective: The study aimed to determine the faculty of the health sciences students' knowledge and attitudes regarding the coronavirus disease 2019 (COVID-19) pandemic. Materials and Methods: This cross-sectional survey was completed with 317 undergraduate students of one health sciences faculty in Turkey. The data were collected between March 1, 2020, and March 15, 2020, by face-to-face interviews using a questionnaire created by the researchers. Number, percentage, mean, standard deviation, and Pearson Chi-square test were used to evaluate the data. Results: In this study, a high proportion of students answered questions about COVID-19 correctly. About 55.8% of the students took partial precautions against COVID-19 to protect themselves against COVID-19 and “frequent washing of hands” was the most common precaution. We determined that the main reasons for not taking any precautions against COVID-19 were “low number of cases in Turkey” and “getting irritated by the mask.” About 98.4% of the participants were entirely/partially following the news on COVID-19, with social media being the most commonly used medium. Female students took more protective measures than male students. The 1st-year students had more positive thoughts about vaccination compared to those in the other classes. Conclusions: Although the knowledge of the students about COVID-19 was good in the first wave of the pandemic, more than half of the students stated that they partially complied with the protective measures.