Callosal abnormalities are mostly described as central nervous system malformations and can be symptomatic or asymptomatic. Herein, we report an autopsy case of a 50-year-old Syrian immigrant male with poor academic performance, presented with partial agenesis of the corpus callosum and colpocephaly. He was evidently asymptomatic until death.The cause of death was determined to be hypothermia. Autosy revealed a corpus callosum of 3 cm only in the anterior part. Posterior part of the corpus callosum, anterior, posterior and hippocampal commissures were absent. On coronal sections, inferior horn of the lateral ventricle was dilated. Histopathological examination showed petechial microhemorrhagic areas and congestion in the brain. This case report was presented to demonstrate a good example of corpus callosum agenesis in asymptomatic individuals except for poor academic performance. Furthermore, this is the first corpus callosum agenesis in medical literature encountered during medicolegal autopsy in an adult case.

Injuries and intoxications are frequent cause of deaths in illicit drug users. Drug abuse is also associated with increase in infectious diseases and decreased level of immunity. Especially collective usage of syringes can be remarkably dangerous. It is difficult to diagnose the fungal infections in people whose immune systems are deficient and spreading of the pathogenic microorganisms through the bloodstream can lead to systemic infections which can cause rapid death. In this article, a case of a 45-year-old man is being presented who died due to illicit drug intoxication. Apparent cardiac involvement with systemic fungal infection has been determined at the autopsy. The case has been evaluated with the literature. The skin and cardiac findings of the case are both rare and educational. Besides, this report aims to draw attention to systemic infectious diseases that can be found at autopsies of persons who had used illicit drugs and it is intended to review the measures for the protection of the autopsy personnel.