The data from this small pilot study suggests that Dermagraft is associated with improved healing of venous ulceration. Following this pilot study, further clinical studies are needed to confirm the validity of these results in 'hard to heal' venous leg ulcers.

Wounds produced following open fasciotomy can be healed by grafting but this requires a second operation. Is Dermagraft, a tissue-engineered human fibroblast-derived dermis that can be applied on an outpatient basis, a viable alternative?

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Background: The encouragement of early ambulation with compression rather than bed-rest becomes a matter of controversy.Aim: To evaluate the benefits of compression and walking exercises in comparison with bed rest in the acute stage of distal deep venous thrombosis.Methods: Twenty-eight patients with distal DVT that were randomized into 2 groups. The first group: 14 patients received low-molecular-weight heparin (LMWH) associated with bed rest & leg elevation for 7-10 days. The second group: 14 patients received LMWH and were allowed to be ambulant after 1-2 days with elastic compression stocks. Patients • assessment was essentially concerning with the reduction of leg pain & swelling and also checking out the propagation of thrombosis and/or development of pulmonary embolism.Results: Leg pain was reduced or abolished in 12/14 patients in the ambulant group compared to 10/14 patients in the bed-rest group. Also; the reduction of limb swelling in the ambulant group was better than that of the bed-rest one.Furthermore; propagation of thrombus was more in the bed-rest group (2/14) compared to the ambulant one (1/14).Conclusion: Patients with acute distal DVT treated with LMWH should be encouraged to walk with medical compression stockings.